Course title
N0450300
Organic Synthesis and Medicinal Chemistry

 suhara yoshitomo Click to show questionnaire result at 2018
Course description
This class is for learning how to proceed synthesis of medicine and related compounds based on organic chemistry I and II. Students learn stereo-selective synthesis, retro-synthetic method, and multi-step synthesis in this class.
Purpose of class
Students learn basic synthetic method for medicine based on retro-sythesis,multi-step synthetic meths.
Goals and objectives
  1. Understanding of synthetic plan to synthesize medicinal chemicals and natural products.
  2. Understanding of a retro-synthetic method that is important in pharmaceutical synthesis.
  3. To master multi-step synthetic scheme about synthesis of compounds.
Language
Japanese
Class schedule

 Class schedule HW assignments (Including preparation and review of the class.) Amount of Time Required
1. Outline of this class Read the textbook of organic chemistry I and II. 140minutes
2. １．Synthetic methods of alkane, alkene, and alkyne (1). Read Sections 1-1 and 1-2 in Chapter 1 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
3. １．Synthetic methods of alkane, alkene, and alkyne (2). Read Section 1-3 in Chapter 1 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
4. ２．Synthetic methods of carbon-carbon bond formation (1). Read Section 7-1~7-5 in Chapter 7 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
5. ２．Synthetic methods of carbon-carbon bond formation (2). Read Section 7-6~7-13 in Chapter 7 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
6. ３．Pericyclic reaction Read Section 10-1~10-2 in Chapter 10 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
7. Intermediate exam Review the textbook and prints. 500minutes
Review a short test in the class.
8. ３．Rearrangement reaction Read Section 10-3~10-6 in Chapter 10 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
9. ３．Retro-synthesis (1). Read Section 11-1~11-3 in Chapter 11 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
10. ３．Retro-synthesis (2). Read Section 11-4~11-7 in Chapter 11 of the textbook. Review the prints. 140minutes
Review a short test in the class. 20minutes
11. ５．Basic structure and names of medicinal compounds. Review the prints and short tests. 140minutes
20minutes
12. ６．Interaction between medicinal compounds and molecules of living body. Review the prints. 140minutes
Review a short test in the class. 20minutes
13. ８．Combinatorial synthesis. Review the prints. 140minutes
Review a short test in the class. 20minutes
14. Terminal exam Review the prints and short tests. 500minutes
Total. - - 2900minutes
Relationship between 'Goals and Objectives' and 'Course Outcomes'

 Intermediate exam Terminal exam short test Total.
1. 15% 15% 10% 40%
2. 10% 15% 5% 30%
3. 10% 15% 5% 30%
Total. 35% 45% 20% -
Evaluation method and criteria
Require total score of 60% and above within small exam 20%, intermediate exam 35％, and terminal exam 45％.
Textbooks and reference materials
Textbook: SHINYUUKIIYAKUHINGOUSEIKAGAKU (HIROKAWA)
Reference material: SOYAKUKAGAKU (TOKYOKAGAKUDOJIN), prints
Prerequisites
Review "Organic Chemistry I" and "Organic Chemistry II".
Office hours and How to contact professors for questions
  • Tuesday and Wednesday PM1:00~5:00
Relation to the environment
Environment-related course (10%)
Regionally-oriented
Non-regionally-oriented course
Development of social and professional independence
  • Course that cultivates an ability for utilizing knowledge
Active-learning course
About half of the classes are interactive
Last modified : Wed Oct 17 07:21:22 JST 2018