Course title
6M0086001
Special Lecture on the Control Systems of Cell Physiology

 yoshimura kenjiro Click to show questionnaire result at 2017
Course content
Cells perceive a variety of information from the environment and regulate the physiological functions using the acquired information. This regulatory system is associated with survival in unicellular organisms and with the expression of tissue functions in multicellular organisms. This lecture aims to facilitate the understanding of the mechanisms for obtaining environmental information, processing information in cells, and controlling the output (especially motility) using the processed information. Existing basic knowledge will be reviewed first, and significant papers on the specific fields will be discussed in detail. The principles of some experimental methods will also be covered.
Purpose of class
To facilitate the understanding of the mechanisms for obtaining environmental information, processing information in cells, and controlling the output (especially motility) using the processed information.
Goals and objectives
  1. I can explain the molecular mechanisms for the stimulus reception in cells.
  2. I can explain cell signal transduction mechanisms.
  3. I can explain the mechanisms for the control of cell motility.
Language
Japanese(English accepted)
Class schedule

 Class schedule HW assignments (Including preparation and review of the class.) Amount of Time Required
1． Electrical excitation of cells
1) Mechanisms of the generation of resting and action potentials
2) Ion channels
3) Cell membrane and membrane proteins 		Preview handout 45minutes
2． Molecular mechanisms for photoreception
1) Cone and rod cells
2) G proteins and G-protein coupled receptors
3) Cyclic nucleotide gated channels 		Preview handout 45minutes
3． Reading a paper about the molecular mechanisms for photoreception Preview handout 45minutes
4． Molecular mechanisms for chemoreception
1) Taste cell
2) Intracellular calcium store
3) Inositol triphosphate
4) Purinergic receptors 		Preview handout 45minutes
5． Reading a paper about the molecular mechanisms for chemoreception Preview handout 45minutes
6． Molecular mechanisms for mechanoreception 1
1) Principles of hearing
2) Hair cells
3) Sense of balance
4) Sense of acceleration
5) Touch reception 		Preview handout 45minutes
7． Molecular mechanisms for mechanoreception 2
1) Piezo channel
2) Hemi-channel and cancer metastasis 		Preview handout 45minutes
8． Molecular mechanisms for intracellular signal transduction
1) Receptor tyrosine kinase 		Preview handout 45minutes
9． Cytoskeleton
1) Actin, microtubule, intermediate filament
2) Localization, structure, and motility of cytoskeleton 		Preview handout 45minutes
10． Cell motility
1) Myosin, dyne, and kinesin
2) Movement based on polymerization
3) Proteins controlling polymerization 		Preview handout 45minutes
11． Cytoskeleton of prokaryotes
1) FtsZ, MreB, and Crew 		Preview handout 45minutes
12． Cell adhesion and cell junction
1) Tight junction, adhesion belt, and desmosome
2) Integrin
3) Gap junction 		Preview handout 45minutes
13． Extracellular matrix
1) Glycosaminoglycan, hyaluronic acid
2) Collagen 		Preview handout 45minutes
14． Final exam and comments Preview handout 45minutes
Total. - - 630minutes
Relationship between 'Goals and Objectives' and 'Course Outcomes'

 Final exam report reading Total.
1. 20% 10% 10% 40%
2. 10% 10% 10% 30%
3. 10% 10% 10% 30%
Total. 40% 30% 30% -
Evaluation method and criteria
Final exam, report, reading
Textbooks and reference materials
Reference book:
Bruce Alberts et al, Molecular Biology of the Cell, 5th ed., Garland Science
Prerequisites
It is expected to have basic knowledge of biology.
Office hours and How to contact professors for questions
  • Anytime. Contact me by e-mail in advance.
Relation to the environment
Non-environment-related course
Regionally-oriented
Non-regionally-oriented course
Development of social and professional independence
  • Course that cultivates an ability for utilizing knowledge
  • Course that cultivates a basic problem-solving skills
Active-learning course
More than one class is interactive
Course by professor with work experience
Work experience Work experience and relevance to the course content if applicatable
N/A N/A
Last modified : Thu Mar 21 15:39:49 JST 2019