Lecture on various organic reactions and reagents
Lecture on synthetic pathway (retro-synthesis) for preparation of various organic compounds such as pharmaceutical products
Lecture on stereocontrol of organic reaction
Lecture on synthetic pathway (retro-synthesis) for preparation of various organic compounds such as pharmaceutical products
Lecture on stereocontrol of organic reaction
Many organic compounds such as pharmaceutical chemicals, agricultural chemicals and electronic materials have been prepared
through synthetic organic reactions. Purposes of this class are understanding on basic organic reactions, reagents and retro-synthesis
analysis for efficient preparation of various organic compounds.
- Understanding on basic C-C bond forming reactions
- Understanding on functionalization of aromatic compounds
- Understanding on functionalization of various organic compounds through oxidation and reduction
- Understanding on reaction mechanism in rearrangement
- Understanding on synthetic scheme
| Class schedule | HW assignments (Including preparation and review of the class.) | Amount of Time Required | |
|---|---|---|---|
| 1. | Significance of synthetic organic chemistry (Contribution to medicinal chemistry) | Reading of syllabus | 200minutes |
| 2. | Reaction with Grignard reagents and lithium reagents | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 3. | Reaction with organo-cooper lithium reagents and acetylides | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 4. | Alkylation with enolate anions and active methine compounds | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 5. | Aldol reaction and Michael addition | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 6. | Other C-C bond forming reactions with carboanions（Wittig reaction etc） | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 7. | Midterm examination and its review | Review of midterm exam | 200minutes |
| 8. | Nitration, halogenation and Friedel-Crafts reaction of aromatic compounds | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 9. | Synthesis of various aromatic compounds using electrophilic aromatic substitution reactions | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 10. | Synthetic reaction using nucleophilic aromatic substitution and benzyne | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 11. | Various oxidation and reduction reactions | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 12. | Stereospecific reactions (addition to alkene) | Prints for preparation and review of the class will be distributed. Reading of these prints. | 200minutes |
| 13. | rearrangement reactions | Prints for preparation and review of the class will be distributed. Reading of these prints. | 230minutes |
| 14. | Term exam and its review | Review of term exam | 200minutes |
| Total. | - | - | 2830minutes |
| mid-term exam | term exam | Total. | |
|---|---|---|---|
| 1. | 15% | 2% | 17% |
| 2. | 15% | 3% | 18% |
| 3. | 15% | 5% | 20% |
| 4. | 0% | 20% | 20% |
| 5. | 0% | 25% | 25% |
| Total. | 45% | 55% | - |
The credit requires over 60% of total scores on the examinations of which include the topics of goals and the objectives.
Textbook: Organic Chemistry by McMurry (Ver 9), Ed by J. McMurry
Lecture prints will be also distributed.
Lecture prints will be also distributed.
- Monday 2:00 pm-4:00 pm
Wednesday 10:00 am-12:00 am
- Non-social and professional independence development course
| Work experience | Work experience and relevance to the course content if applicatable |
|---|---|
| N/A | N/A |
Last modified : Sat Mar 21 12:13:40 JST 2020