Medicinal Chemistry and Organic Synthesis

Course title

6M005900

Click to show questionnaire result at 2018

Course content

This class provided topics in research area of Pharmaceutical Synthetic Chemistry, Bioorganic and Synthetic Chemistry and Functional Molecular Sciences, which are important for research and development of medicine.

Purpose of class

Understanding of pharmaceutical synthetic chemistry as well as the topics of research field of medicinal chemistry.

Goals and objectives

To understand Pharmaceutical Synthetic Chemistry, Bioorganic and Synthetic Chemistry and Functional Molecular Sciences.
To understand synthetic methods for the total synthesis of organic compounds.
To understand methods for separation and analysis of enantiomers and determination of stereochemistry.

Language

Japanese

Class schedule

	Class schedule	HW assignments (Including preparation and review of the class.)	Amount of Time Required
1．	History of drugs and drug companies	Review prints and write a report.	120minutes
1．	History of drugs and drug companies	Next learning preparation	60minutes
2．	Classification of drugs derived from natural products and their restosynthesis I	Review prints and write a report.	120minutes
2．		Next learning preparation	60minutes
3．	lassification of drugs derived from natural products and their restosynthesis II	Review prints and write a report.	120minutes
3．		Next learning preparation	60minutes
4．	Carbohydrates and amino acids	Review prints and write a report.	120minutes
4．	Carbohydrates and amino acids	Next learning preparation	60minutes
5．	Heterocyclic compounds	Review prints and write a report.	120minutes
5．	Heterocyclic compounds	Next learning preparation	60minutes
6．	Protective groups	Review prints and write a report.	120minutes
6．	Protective groups	Next learning preparation	60minutes
7．	Organic synthesis utilized organic metals	Review prints and write a report.	120minutes
7．	Organic synthesis utilized organic metals	Next learning preparation	60minutes
8．	Methods of separation of enantiomer	Review prints and write a report.	120minutes
8．	Methods of separation of enantiomer	Next learning preparation	60minutes
9．	Asymmetric syntheses	Review prints and write a report.	120minutes
9．	Asymmetric syntheses	Next learning preparation	60minutes
10．	Mechanism of activity of biologically active agents	Review prints and write a report.	120minutes
10．	Mechanism of activity of biologically active agents	Next learning preparation	60minutes
11．	Structure analyses of receptors and enzymes	Review prints and write a report.	120minutes
11．	Structure analyses of receptors and enzymes	Next learning preparation	60minutes
12．	Interaction between proteins and small molecules	Review prints and write a report.	120minutes
12．	Interaction between proteins and small molecules	Next learning preparation	60minutes
13．	Synthesis of small molecules	Review prints and write a report.	120minutes
13．	Synthesis of small molecules	Next learning preparation	60minutes
14．	Mechanism of actions of small molecules	Review prints and write a report.	120minutes
Total.	-	-	2460minutes

Relationship between 'Goals and Objectives' and 'Course Outcomes'

	report	including mini test	Total.
1.	20%	10%	30%
2.	20%	15%	35%
3.	20%	15%	35%
Total.	60%	40%	-

Evaluation method and criteria

Class attendance and attitude for the lecture (40%) and report (60%).

Textbooks and reference materials

References: Top Drug karamanabu Souyakukagaku by Yukigoseikagakukyokai (Tokyokagakudojin)
Souyaku-Yukigosei karano approach- by Yasuyuki Kita and Tetsuo Hiraoka (Tokyokagakudojin)
Originally printed-out texts according to the topics will be provided.

Prerequisites

Reading textbooks of medicinal chemistry are recommended to attend to this class.

Office hours and How to contact professors for questions

Tuesday and Wednesday PM1:00~5:00

Regionally-oriented

Non-regionally-oriented course

Development of social and professional independence

Course that cultivates a basic problem-solving skills

Active-learning course

About half of the classes are interactive

Course by professor with work experience

Work experience	Work experience and relevance to the course content if applicable
Applicable	Using experiences in synthetic organic chemistry, this class teaches the basic knowledge and concepts necessary for medicinal chemistry.

Education related SDGs:the Sustainable Development Goals

9.INDUSTRY, INNOVATION AND INFRASTRUCTURE

Last modified : Sun Mar 21 15:13:52 JST 2021