Chemical biology is a way of understanding biology as a fusion of organic, inorganic, physical, and analytical chemistry.
A broad range of disciplines from biochemistry to chemical biology will be discussed focusing on the background, history,
and the methodology of it which contributed to development of chemical biology.
- Understanding for the elements and the molecule of which participates in the biological systems.
- Understanding for the structure and activity relationship of the molecules in the biological systems.
- Understanding for the way of maitain the biological system
| Class schedule | HW assignments (Including preparation and review of the class.) | Amount of Time Required | |
|---|---|---|---|
| 1． | The elements and chemicals of biological systems | What elements are aboundant in a biological organism? What are the major chemicals in a biological organism? |
200minutes |
| 2． | Amino acids, a monomer that construct proteins structure of proteins | Why only L-amino acid is available in protein? How L-amino acids are selected and accumulated in nature. | 200minutes |
| 3． | The structure of proteins. What determine the structure of the protein? | State the definition of primary, secondary, tirtialy and qurtenary structure of the protein | 200minutes |
| 4． | Folding and denaturing of the protein | Folding and denaturing of the protein is reversible process. HOw can you make low egg fron boild egg? | 200minutes |
| 5． | Purification of the protein, separation by size of the protein, separation by the character of the protein | Centrifuge, Ultrafiltration, gel filtration, electrophoresis, chromatography | 200minutes |
| 6． | Enzyme, mechanism and inhibition | Foundations of chemical biology, 46-50 | 200minutes |
| 7． | Summary, te relationship between structure of the protein and the role of the protein | What kind of function does protein have? That depend on their structural nanure. | 200minutes |
| 8． | Enzymes in molecular biology | How they works in each roles, DNA polymerase, restriction enzyme (DNAse), Ligase | 200minutes |
| 9． | Chemistry of virus | Virus is not living organism. What molecules construct a virus? | 200minutes |
| 10． | DNA extruction from the cell and purification | How can we adopt the tools that useful for protein purification? | 200minutes |
| 11． | Vector construction | How can we construct the desired vector from host vector and insert DNAs? | 200minutes |
| 12． | Preparation od insert DNAs | How can we prerpare insert DNA from genome or plasmide? | 200minutes |
| 13． | Evaluation of the vector constructed | How can we make a judge, if the constructed vector is eight one or not? | 200minutes |
| 14． | Transformation, screening of the colony and protein suynthsis | How can we select a right colony that might have desired vector? | 200minutes |
| Total. | - | - | 2800minutes |
| Presentation | Essay | Total. | |
|---|---|---|---|
| 1. | 25% | 25% | |
| 2. | 25% | 25% | 50% |
| 3. | 25% | 25% | |
| Total. | 50% | 50% | - |
Presentation: 50%
Essay: 50%
The credit requires over 60% of total scores on the examinations of which include the topics of "goals and the objectives".
Essay: 50%
The credit requires over 60% of total scores on the examinations of which include the topics of "goals and the objectives".
Essentials of chemical biology, Andrew Miller and Julian Tanner, Willey
Organic chemistry, Inorganic chemistry, Physical chemistry, Analytical chemistry, Biological chemistry
- Course that cultivates an ability for utilizing knowledge
- Course that cultivates a basic problem-solving skills
| Work experience | Work experience and relevance to the course content if applicable |
|---|---|
| N/A | N/A |
Last modified : Fri Mar 18 23:12:48 JST 2022