生命創薬科学特論では、最新の医薬品開発の動向と創薬研究の基盤となる化学・生物学的手法を学びます。特に、中枢神経系疾患やウイルス感染症を対象とした新規治療薬の設計、低分子化合物の探索、作用機序の解明に焦点を当てます。実際の研究事例を交えながら、創薬における課題や今後の展望について議論し、次世代の創薬研究者に必要な知識と応用力を養います。
In Medicinal Chemistry and Organic Synthesis, students learn about the latest trends in drug development and the chemical and biological methods that form the basis of drug discovery research. Particular focus is placed on the design of novel therapeutics for central nervous system diseases and viral infections, the search for small molecule compounds and the elucidation of their mechanisms of action. Using actual research case studies, the course discusses challenges and future prospects in drug discovery and develops the knowledge and applied skills necessary for the next generation of drug discovery researchers.
In Medicinal Chemistry and Organic Synthesis, students learn about the latest trends in drug development and the chemical and biological methods that form the basis of drug discovery research. Particular focus is placed on the design of novel therapeutics for central nervous system diseases and viral infections, the search for small molecule compounds and the elucidation of their mechanisms of action. Using actual research case studies, the course discusses challenges and future prospects in drug discovery and develops the knowledge and applied skills necessary for the next generation of drug discovery researchers.
本講義では、生命創薬科学の最新の研究動向を理解し、新規医薬品の開発に必要な基礎知識と応用力を身につけることを目的とします。
The aim of this course is to understand the latest research trends in life and drug discovery science and to acquire the basic knowledge and applied skills required for the development of novel drugs.
The aim of this course is to understand the latest research trends in life and drug discovery science and to acquire the basic knowledge and applied skills required for the development of novel drugs.
- 医薬品開発の各段階（標的探索、リード化合物の最適化、前臨床・臨床試験）の概要を説明できる。
The course provides an overview of the various stages of drug development (target discovery, lead compound optimisation, preclinical and clinical trials). - 各種の疾病に対する低分子化合物から抗体薬までの設計原理と作用機序について説明できる。
Be able to explain the design principles and mechanisms of action of small molecule compounds to antibody drugs for various diseases. - 医薬品開発の最前線に関する論文や研究事例を理解し、説明できる。
Understand and describe articles and research case studies on the frontiers of drug development.
| 課題 (Tasks) | 小テスト (Small exam) | 期末試験 (Final exam) | Total. | |
|---|---|---|---|---|
| 1. | 10% | 5% | 10% | 25% |
| 2. | 20% | 5% | 10% | 35% |
| 3. | 20% | 10% | 10% | 40% |
| Total. | 50% | 20% | 30% | - |
| Class schedule | HW assignments (Including preparation and review of the class.) | Amount of Time Required | |
|---|---|---|---|
| 1． | ・化合物のin vitro試験とin vivo試験について ・IC50およびEC50の求め方 ・医薬品のプロドラッグ化について • In vitro and in vivo studies of compounds. • How to determine IC50 and EC50. • Prodrugisation of pharmaceuticals |
市販されている医薬品の中で、プロドラッグ化されているものについて調べ、次回の授業でプレゼンテーションを行うための資料を作成する。 Research on prodrugisation of drugs on the market and prepare materials for presentation in the next class. |
150minutes |
| 2． | ・アゴニスト、アンタゴニストとは？ ・パーシャルアゴニストについて • Agonists and antagonists • Partial agonists |
市販されている医薬品の中で、パーシャルアゴニストについて調べ、次回の授業でプレゼンテーションを行うための資料を作成する。 Research partial agonists among the medicines on the market and prepare materials for presentation in the next class. |
150minutes |
| 3． | ・中分子創薬について • What is a medium-molecule drug discovery? |
中分子創薬について調べ、次回の授業でプレゼンテーションを行うための資料を作成する。 Research on intermediate molecule drug discovery and prepare materials for presentation in the next lesson. |
150minutes |
| 4． | ・アルツハイマー病治療薬について • About Alzheimer's disease drugs. |
抗体薬について調べ、次回の授業でプレゼンテーションを行うための資料を作成する。 Research antibody drugs and prepare material for presentation in the next class. |
150minutes |
| 5． | ・新型コロナウイルスとその治療薬開発について • New coronaviruses and the development of therapeutic agents. |
医薬品として使用されている抗ウイルス剤にはどのようなものがあるか調べてまとめる。 Research and summarise the types of antiviral drugs used as medicines. |
150minutes |
| 6． | ・抗がん剤について • Anti-cancer drugs |
新しい抗がん剤としてどのような薬剤が開発されているのか、その概要をまとめる。 To summarise what kind of drugs are being developed as new anti-cancer drugs. |
150minutes |
| 7． | 特別講師による講演 Lectures by special lecturers |
特別講師の講演内容について記述し、さらに自分で調べたことを追加してまとめる。 Describe the content of the lectures given by special lecturers and summarise with additional information from your own research. |
150minutes |
| Total. | - | - | 1050minutes |
毎回の課題を50%、小テストを20%、期末試験を30%として、合計60%以上を取得した方に単位認定します。毎回休まずに講義を受けて、評価できるレポートを提出すれば、単位認定されます。
Credit will be awarded to students who obtain a total of at least 60%, consisting of 50% on each assignment, 20% on the quiz and 30% on the final examination. If you attend every lecture without missing a lecture and submit an assessable report, you will be awarded credits.
Credit will be awarded to students who obtain a total of at least 60%, consisting of 50% on each assignment, 20% on the quiz and 30% on the final examination. If you attend every lecture without missing a lecture and submit an assessable report, you will be awarded credits.
| ways of feedback | specific contents about "Other" |
|---|---|
| Feedback in the class |
創薬化学について記載されている書籍全般
General books describing drug discovery chemistry
General books describing drug discovery chemistry
創薬化学の本を読んでおくと理解が進みます。
Reading books on medicinal chemistry will be recommended to understand the subject.
Reading books on medicinal chemistry will be recommended to understand the subject.
- 授業終了後から午後６時の間に研究室に来てください。
Come to the laboratory between the end of class and 6pm.
- Course that cultivates an ability for utilizing knowledge
| Work experience | Work experience and relevance to the course content if applicable |
|---|---|
| N/A | 該当しない |
- 3.GOOD HEALTH AND WELL-BEING
- 9.INDUSTRY, INNOVATION AND INFRASTRUCTURE
Last modified : Tue Mar 11 04:09:59 JST 2025