Medicinal Chemistry and Organic Synthesis/Exercise1

Course title

6M175100

	SUHARA Yoshitomo
	HIROTA Yoshihisa

Course content

To understand synthetic medicinal chemistry, synthesis of compounds library and evaluation of their biological activities will be examined. Based on those findings and the pharmacophore analysis, compounds possess more potent activity will be designed.

Goals and objectives

To acquire knowledge and skills of designing and synthesis of functional molecules based on biologically active substances.
To understand the structure activity relationship of biologically active compounds and the influence on the living body at the gene or cell level.
Understanding of the design of biologically active molecules.

Language

Japanese

Class schedule

Biologically active compounds will be synthesized. For these compound groups, evaluation of biological activity will be carried out using cells and the activity correlation will be also examined. Pharmacophore analysis is carried out based on these information, and a compound having strong physiological activity is designed.

Evaluation method and criteria

This course is graded on the basis of 40% presentation of the assignment and 60% report. A total of 60% will be required to pass the course. No examinations will be given. You can get 60 points or more if you attend every lecture, present the assignment, and submit the report.

Feedback on exams, assignments, etc.

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Textbooks and reference materials

References: Top Drug karamanabu Souyakukagaku by Yukigoseikagakukyokai (Tokyokagakudojin)
Souyaku-Yukigosei karano approach- by Yasuyuki Kita and Tetsuo Hiraoka (Tokyokagakudojin)

Prerequisites

Read textbooks

Office hours and How to contact professors for questions