Special Lecture on Cell Physiology

Course title

6M226900

Course content

In recent years, the field of cell biology has made remarkable progress, and molecules, phenomena, and physiological mechanisms have been revealed in various research fields. Because abnormalities in the basic functions of cells are associated with diseases, the basic functions of cells are recognized to be important also from a medical perspective. This special lecture deals with signal transduction and functions of cell motility and cytoskeleton using sensory cells as examples. We will discuss that diverse biological functions are possible through the combination of universal mechanisms that are involved in many physiological phenomena and specific mechanisms that are used only for particular physiological phenomena.

Purpose of class

Understand cell signal transduction and the function of the cytoskeleton using specific examples such as sensory cells.

Goals and objectives

I can explain the molecular mechanism of stimulus perception in cells
I can explain the information transduction mechanism in cells
I can explain the function of cytoskeleton and cell motility

Relationship between 'Goals and Objectives' and 'Course Outcomes'

	Test or report	Total.
1.	40%	40%
2.	30%	30%
3.	30%	30%
Total.	100%	-

Language

Japanese(English accepted)

Class schedule

	Class schedule	HW assignments (Including preparation and review of the class.)	Amount of Time Required
1．	Guidance Electrical excitation of cells + Mechanisms how resting and action potentials are generated + Ion channels + Cell membrane and membrane proteins	Review relevant handout and paper.	180minutes
2．	Molecular mechanism of photoreception + Rod and cone cells + G protein and G-protein coupled receptor + cyclic nucleotide gated channel	Review relevant handout and paper.	180minutes
3．	Molecular mechanism of chemoreception + Taste cells + Intracellular calcium store + Inositol-3-triphosphate + Purinergic receptor	Review relevant handout and paper.	180minutes
4．	Molecular mechanism of mechanoreception 1 + Principles of hearing + Hair cells + Balance + Sense of acceleration + Touch sensation	Review relevant handout and paper.	180minutes
5．	Molecular mechanism of mechanoreception 2 + Piezo channels + Hemichannel and cancer metastasis	Review relevant handout and paper.	180minutes
6．	Cytoskeleton + Actin, microtubule, intermediate filament + Localization, structure, and motility of cytoskeleton	Review relevant handout and paper.	180minutes
7．	Cell Motility + Myosin, dynein, kinesin + Motility based on polymerization + Proteins regulating polymerization	Review relevant handout and paper.	180minutes
8．	3Qの授業なのでこの回の授業はない	該当しない	0minutes
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Total.	-	-	1260minutes