Medicinal Chemistry and Organic Synthesis/Exercise1

This course focuses on drug discovery, biomedicine, and disease treatment, providing multi-disciplinary instruction in synthetic chemistry, biochemistry, molecular biology, and pharmacology. By practicing organic chemistry research directly linked to drug discovery, students aim to master advanced knowledge and technical skills required for the design and synthesis of functional molecules based on bioactive substances. Furthermore, the course seeks to deepen students' systematic understanding of Structure-Activity Relationships (SAR) and the effects of bioactive substances on biological systems at the genetic and cellular levels, by organically integrating chemical and biological insights.

This course provides a detailed exploration of the "chemical-biological fusion approach," which is essential at the forefront of drug discovery and biomedicine. Initially, we will examine precise molecular design and synthetic strategies from an organic chemistry perspective, using bioactive substances as lead compounds. Subsequently, students will learn how to analyze and evaluate the impact of synthesized molecules on intracellular target factors and gene expression using biochemical, molecular biological, and pharmacological methodologies. Beyond acquiring knowledge, students will develop the ability to construct systematic theories for next-generation drug development through the analysis of SAR processes.

1. Master drug discovery techniques through bioactive molecule synthesis.
2. Integrate chemical and biological views on SAR and cellular impacts.
3. Independently design original bioactive molecules.

Japanese

Biologically active compounds will be synthesized. For these compound groups, evaluation of biological activity will be carried out using cells and the activity correlation will be also examined. Pharmacophore analysis is carried out based on these information, and a compound having strong physiological activity is designed.

This course is graded on the basis of 40% presentation of the assignment and 60% report. A total of 60% will be required to pass the course. No examinations will be given. You can get 60 points or more if you attend every lecture, present the assignment, and submit the report.

References: Top Drug karamanabu Souyakukagaku by Yukigoseikagakukyokai (Tokyokagakudojin)
Souyaku-Yukigosei karano approach- by Yasuyuki Kita and Tetsuo Hiraoka (Tokyokagakudojin)

Read textbooks

• Thursday, Friday from 1 PM to 5 PM（Suhara）
• Tuesdays and Thursdays during lunch break, or immediately after class.（Hirota）

Non-regionally-oriented course

• Course that cultivates an ability for utilizing knowledge
• Course that cultivates a basic self-management skills

More than one class is interactive

• 3.GOOD HEALTH AND WELL-BEING
• 4.QUALITY EDUCATION