Laboratory Course of Analytical Chemistry

Course title

D0009000

	OGUCHI Hiroyuki
	LEE SO YOON
	SEGAWA Hiroki
	KAWANO Yasuro
and more...
	NAKAJIMA Hiromitsu
	FUSE Hiroyuki
	MASADOME Takashi

Middle-level Diploma Policy (mDP)

Program / Major	mDP	Goals
Chemistry and Biotechnology	A	確かな基礎と物質化学の専門知識に基づいて問題を解決することができる。
Chemistry and Biotechnology	E	統合的な視点から計画を立て、課題を達成することができる。

Purpose of class

The objective of this course is to deepen students’ understanding of fundamental analytical chemistry techniques through hands-on laboratory experiments, with a focus on volumetric and gravimetric analysis.

Specifically, students will:
Understand the principles of quantitative analysis using acid–base titration, chelate titration, and precipitation reactions.
Acquire fundamental laboratory skills, including preparation and standardization of standard solutions, precipitation, washing, drying, and ignition.
Develop the ability to organize experimental data, perform calculations, and analyze experimental errors.

Course description

Students are divided into six groups, and experimental themes are conducted in a rotation system.
Exercises are conducted in a separate classroom, focusing on calculation practice and review of fundamental concepts in analytical chemistry.

Goals and objectives

Conduct basic analytical chemistry experiments with due consideration for safety and environmental protection.
Perform fundamental analytical chemistry calculations related to solution concentration, titration reactions, and gravimetric analysis.
Prepare well-structured and properly formatted laboratory reports.

Relationship between 'Goals and Objectives' and 'Course Outcomes'

	Report	Exercise	Total.
1.	20%		20%
2.	30%	20%	50%
3.	30%		30%
Total.	80%	20%	-

Evaluation method and criteria

Learning outcomes (1)–(3) are assessed based on:
・Laboratory reports (including evaluation of experimental attitude and oral questioning at the end of each experiment)
・Exercise tests

Grading Policy:
Laboratory reports: 80 points
Exercise tests: 20 points

A total score of 60 points or higher is required to pass the course.

Language

Japanese(English accepted)

Class schedule

	Class schedule	HW assignments (Including preparation and review of the class.)	Amount of Time Required
1.	Laboratory Preparation Laboratory safety rules Handling of reagents and waste solutions Accident prevention Handling of experimental results Preparation of laboratory apparatus	Review the laboratory manual	200minutes
2.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
3.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
4.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
5.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
6.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
7.	(In each session, two groups perform Experiment A, two groups perform Experiment B, and the remaining two groups attend exercises.) Experiment A: Acid–Base Titration Preparation and standardization of hydrochloric acid standard solution Quantitative analysis of NaOH–Na₂CO₃ mixtures Principles of acid–base titration and endpoint determination Experiment B: Gravimetric Analysis of Sulfate Ion Determination of sulfate ion (SO₄²⁻) in crystalline copper sulfate Precipitation, washing, drying, and weighing procedures Principles of gravimetric analysis Exercises (Exercises 1–3) Concentration calculations in analytical chemistry Titration calculations and error analysis Calculation exercises for gravimetric analysis	Review the laboratory manual	200minutes
8.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
9.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
10.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
11.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
12.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
13.	(In each session, two groups perform Experiment C, two groups perform Experiment D, and the remaining two groups attend exercises.) Experiment C: Gravimetric Analysis of Nickel Quantitative determination of nickel using dimethylglyoxime as a precipitating agent Precipitation, washing, drying, and ignition Discussion of precision and sources of error in gravimetric analysis Experiment D: Chelate Titration Volumetric analysis of metal ions using EDTA Endpoint determination using indicators Characteristics and applications of chelate titration Exercises (Exercises 4–6) Calculation exercises for chelate titration Methods for organizing and processing experimental data	Review the laboratory manual	200minutes
14.	Final Examination Review of Exercises 1–6	Review the laboratory manual	200minutes
Total.	-	-	2800minutes

Feedback on exams, assignments, etc.

ways of feedback	specific contents about "Other"
Feedback in the class

Textbooks and reference materials

Textbook: Distributed via ScombZ

References:
Shin Bunseki Kagaku Jikken (New Analytical Chemistry Laboratory), edited by the Hokkaido Branch of the Japan Society for Analytical Chemistry, Kagaku-Dojin, and other relevant books.

Prerequisites

Students are expected to have completed coursework in Analytical Chemistry prior to enrolling.

Office hours and How to contact professors for questions